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Keep an eye on Closely (one)crofelemer increases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Crofelemer has the potential to inhibit CYP3A4 at concentrations envisioned in the gut; not likely to inhibit systemically since minimally absorbed.iloperidone will increase levels of diazepam b

Reserve concomitant prescribing of these medication in patients for whom other procedure solutions are insufficient. Limit dosages and durations to the minimum amount expected. Observe carefully for signs of respiratory depression and sedation.If a affected individual develops any of these reactions, the drug really should be discontinued. Individu